授课教师：胡美荣，刘伟丰

教师简介（中英文）：

胡美荣，博士，毕业于中国科学院微生物研究所，2009至2022年先后在中国科学院生物物理所、中国科学院微生物研究所工作，任高级工程师。在SCI期刊Angew. Chem. Int. Ed；Microb cell fact、Int. J. Biol. Macromo等SCI杂志上发表论文近10篇，主持国家和省部级及企业项目14项，包括青年自然科学基金、中国科学院STS重点项目，河北省科学院以及横向项目；申请专利18项，授权专利14项。主要从事大肠杆菌和毕赤酵母的蛋白表达平台的搭建，已经实现了近20种酶的高效重组表达和商业转化。其中生物催化法生产氨基葡萄糖、α-熊果苷以及葡萄糖醛酸技术,以及全细胞发酵法生产肌醇等技术转让经费达千万元。

Hu Meirong, doctor, graduated from the Institute of Microbiology, Chinese Academy of Sciences. From 2009 to 2022, she worked in the Institute of Biophysics, Chinese Academy of Sciences, and the Institute of Microbiology, Chinese Academy of Sciences as a senior engineer. Nearly 10 papers were published in journals which included Angelw Chem. Int. Ed, Biol. Macromo, Microb cell fact and Int. J. Professor Hu presided 14 national, provincial, ministerial, and enterprise projects including Young Scientists Fund, STS key projects of the Chinese Academy of Sciences, Hebei Academy of Sciences, and horizontal projects, and applied for 18 patents and authorize 14 patents. She is mainly engaged in the construction of protein expression platforms for Escherichia coli and Pichia pastoris, and has achieved efficient recombinant expression and commercial transformation of nearly 20 enzymes. Among them, the biocatalytic method produces glucosamine α- The transfer funds for technologies such as arbutin and glucuronic acid, as well as the production of inositol through whole cell fermentation, amount to millions RMB.

刘伟丰，博士。毕业于清华大学，先后在长春生物制品研究所，中国科学院微生物研究所工作，任副研究员。现任微元合成生物技术（北京）有限公司技术总监。主要从事工业生物技术研究，以天然产物、生物基材料等高附加值化合物的高效生物合成为目标，对微生物细胞工厂进行改造，获得了实现了一系列目标产物的高效合成。主持国家重点研发计划子课题、国家自然科学基金等各级项目14项，主持横向项目合同金额近2000万元。在Metabolic engineering等SCI收录期刊上发表论文30余篇，申请/授权专利10余项，其中PCT专利2项。针对萜类化合物、生物材料单体、氨基酸衍生物等产品，建立了一系列新型生物制造路线，转化率等技术指标均超过现有国内外报道。在此过程中，开发了一系列高效的合成生物学调控元件、蛋白质进化及筛选平台、工业菌株基因编辑平台。

Liu Weifeng, Ph.D. He graduated from Tsinghua University and worked as an associate researcher in Changchun Institute of Biological Products and Institute of Microbiology, Chinese Academy of Sciences. He is working for the Technical Director of Microelement Synthetic Biotechnology (Beijing) Co., Ltd now. With the goal of efficient biosynthesis of high value-added compounds such as natural products and bio based materials, Professor Liu mainly engaged in industrial biotechnology research, transformed microbial cell factories, and achieved efficient synthesis of a series of target products. Professor Liu presided 14 national, provincial, ministerial, and enterprise projects including Young Scientists Fund, STS key projects of the Chinese Academy of Sciences, Hebei Academy of Sciences, and horizontal project. Nearly 30 papers were published in journals which included Metabolic Engineering and applied for/granted over 10 patents, including 2 PCT patents. A series of new biological manufacturing routes have been established for products such as terpenoids, biomaterial monomers, and amino acid derivatives, with conversion rates and other technical indicators exceeding existing domestic and foreign reports. A series of efficient synthetic biology regulatory elements, protein evolution and screening platforms, and industrial strain genome editing platforms have been developed by his laboratory.

课程简介（中英文）：

合成生物学是工程学原理与方法应用于生物技术领域新兴交叉学科。2003年首次定义为基于系统生物学的遗传工程和工程方法的人工生物系统研究。合成生物学正在催生着新的生物技术革命。针对我国能源、环境、健康等方面的广泛需求，面向生物医药、生物能源和生物基产品等重要生物产品的合成生物学理论与技术的基础研究任务任重而道远，让我们听下有着丰富的科研开发和市场经验的老师是如何设计并合成相关的细胞工厂和分子机器。

Synthetic biology is a new cross discipline of engineering principles and methods applied to biotechnology. In 2003, synthetic biology was first defined as the study of artificial biological systems based on genetic engineering and engineering methods in systems biology. Synthetic biology brings a new biological technological innovation. As our extensive demand for energy, environment, health and other aspects, the basic research task of synthetic biology theory and technology for important biological products such as biomedicine, bioenergy and bio based products has a long way to go. Let's listen to how teachers with rich scientific research and development and market experience design and synthesize related cell factories and molecular machines.